ArticleScientific data2026
Light sheet microscopy imaging dataset of CAR-T-cell-mediated cytotoxicity.
Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Light sheet microscopy imaging dataset of CAR-T-cell-mediated cytotoxicity.Scientific data · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on CAR-T cell states is crucial for understanding the mechanisms of immunotherapy. Previous studies in live cells have been primarily limited by phototoxicity, resolution, and throughput, making it difficult to conduct further research and observations on cell states. To enable more detailed studies of cell states, we developed a microscopy imaging system with subcellular resolution, low phototoxicity, high imaging throughput, and automated data reconstruction. Using this system, we have generated and shared over 400 image sets that capture the cytotoxic effects of CAR-T cells on tumor cells. The data provide an isotropic spatial resolution of 320 nm, a temporal resolution of up to 2.5 seconds per volume, and long-term observations spanning up to 5 hours. This study reports an imaging system that fills an essential gap in the field, offers valuable insights into the cytotoxic processes of CAR-T cells, and significantly advances research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.