ArticleNPJ science of food2026
Food-medicine homology nanostructures: self-assembly, sustained release, and extended anti-inflammatory effects of Eucommia ulmoides nanoparticles.
Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exosome-like nanoparticles derived fromInternational journal of pharmaceutics: X · 2026Article
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14 authors.
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Abstract
Plant-derived self-assembled nanoparticles, especially from food-medicine homology sources, are gaining attention, yet their structure-function relationships remain unclear. This study identified such nanoparticles from leaf decoction of Eucommia ulmoides, a key plant in traditional Asian medicine and diet, termed EUPs. These spherical particles (~287.8 nm) were primarily composed of polysaccharides and polyphenols, with 268 polyphenolic compounds detected via UPLC-QTOF-MS. Stepwise dissociation-ultrafiltration and spectroscopic analyses revealed that polyphenols were bound to the polysaccharide through noncovalent interactions, including hydrogen bonding and hydrophobic forces, forming a layered structure with sustained-release and thermo-responsive properties. Compared with free polyphenols, EUPs exhibited significantly prolonged anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages, reflected by the suppression of key inflammatory cytokines, including TNF-α, IL-6 and NO. Therefore, it aims to offer mechanistic insights into the multi-component synergistic anti-inflammatory effects of E. ulmoides and supporting the material basis of food-medicine homology.
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