Evidence map›Paper›PMID 41680183›Full record

ArticleNature communications2026

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.

Veronica Bergo, Pavlos Bousounis, Giang To Vu, Mélodie Douté, Aikaterini Polyzou, Maria-Eleni Lalioti, Bogdan B Grigorash, Lyudmila Tsurkan, Nicholas Morchel, Ward Deboutte and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Veronica Bergo *Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. bergo95veronica@gmail.com.
Pavlos Bousounis *Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Giang To Vu *Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS, INSERM, Université Côte d'Azur, Nice, France.
Mélodie DoutéDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1926-9718
Aikaterini PolyzouMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Maria-Eleni LaliotiDepartment of Health Sciences and Technology, Laboratory of Stem Cell Biology and Ageing, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
Bogdan B GrigorashInstitute for Research on Cancer and Aging of Nice (IRCAN), CNRS, INSERM, Université Côte d'Azur, Nice, France.ORCID http://orcid.org/0000-0002-3836-7217
Lyudmila TsurkanDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Nicholas MorchelDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ward DeboutteMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-3829-1056
Frédéric BrauInstitute for Research on Cancer and Aging of Nice (IRCAN), CNRS, INSERM, Université Côte d'Azur, Nice, France.
Thomas MankeMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3702-0868
SagarDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Faculty of Medicine, Freiburg University Medical Center, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-8657-4704
Hind MedyoufDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-4652-9455
Dmitry V BulavinInstitute for Research on Cancer and Aging of Nice (IRCAN), CNRS, INSERM, Université Côte d'Azur, Nice, France.
Nina Cabezas-WallscheidDepartment of Health Sciences and Technology, Laboratory of Stem Cell Biology and Ageing, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
Marta DereckaDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA. Marta.Derecka@stjude.org.ORCID http://orcid.org/0000-0001-6265-9781
Eirini TrompoukiMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Eirini.TROMPOUKI@univ-cotedazur.fr.ORCID http://orcid.org/0000-0002-7242-8810

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Agence Nationale de la Recherche (French National Research Agency) ANR-23-CE14-0017 and LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01Deutsche Forschungsgemeinschaft (German Research Foundation) 322977937/GRK2344-MeInBioDeutsche Forschungsgemeinschaft (German Research Foundation) GZ TR 1478/2-1EC | EU Framework Programme for Research and Innovation H2020 | H2020 Euratom (H2020 Euratom Research and Training Programme 2014-2018) ARCH; Project #813091EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-Stg-2017 (VitASTEM, 759206)European Hematology Association (EHA) bilateral collaborative grant 2022Fondation pour la Recherche Médicale (Foundation for Medical Research in France) AJE202010012488NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

"Inflammaging", the chronic increase in inflammatory signaling with age, remains poorly understood in hematopoietic aging. Here, we identify the innate immune RNA sensor melanoma differentiation-associated protein 5 (MDA5) as an important factor of hematopoietic stem cell (HSC) aging. Aged Mda5

Indexed as

AgingCellular SenescenceHematopoiesisHematopoietic Stem CellsInflammationInterferon-Induced Helicase, IFIH1ProteostasisAnimalsEukaryotic Initiation Factor-2Heat Shock Transcription FactorsMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionEukaryotic Initiation Factor-2Heat Shock Transcription FactorsHsf1 protein, mouseIfih1 protein, mouseInterferon-Induced Helicase, IFIH1

Identifiers

PMID41680183
PMCPMC12905429

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.