ArticleTranslational psychiatry2026
Eukaryotic initiation factor 4E: a key factor of traumatic stress-induced depression-related cognitive decline at different age.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Depression in patients with cognitive impairment may be a risk factor for dementia. A previous study demonstrated that patients with treatment-resistant depression (TRD), characterized by poor response to adequate antidepressant treatment, exhibit pronounced cognitive impairment. Although depression in midlife or later life are associated with an increased risk of developing dementia, the mechanisms linking cognitive impairment and midlife depression remain poorly understood. A recent study revealed that downregulation of the γ-aminobutyric acid mediated (GABAergic) system and increased phosphorylation of eukaryotic translation initiation factor (eIF4E) are strongly associated with cognitive dysfunction and depressive symptoms. Hence, we hypothesized that the GABAergic system and eIF4E phosphorylation are involved in cognitive dysfunction and depression, particularly forms resistant to treatment, with increased aging. In the present study, we used a mouse model exhibiting antidepressant-resistant symptoms induced by traumatic stress in young- and middle-aged mice. Depression-like behavior was observed after traumatic stress exposure in both young and middle-aged mice. However, cognitive impairment induced by traumatic stress was worse in middle-aged mice. Moreover, the expression of GABA
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