Evidence map›Paper›PMID 41680136›Full record

SynthesisTranslational psychiatry2026

Depression and anxiety in interstitial lung disease: a systematic review, meta-analysis and Mendelian randomization.

Dongru Du, Jiangyue Qin, Guangyue Zhang, Lijuan Gao, Yanqiu Wu, Zhenni Chen, Chun Wan, Ting Yang, Fengming Luo, Yongchun Shen

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dongru Du *Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Jiangyue Qin *General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Guangyue ZhangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
Lijuan GaoDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Yanqiu WuDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Zhenni ChenDepartment of Medical Affairs, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Chun WanDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Ting YangDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China.
Fengming LuoDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China. fengmingluo@outlook.com.ORCID http://orcid.org/0000-0001-9267-3437
Yongchun ShenDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610064, People's Republic of China. shen_yongchun@126.com.ORCID http://orcid.org/0000-0002-8142-1792

Funding

National Natural Science Foundation of China (National Science Foundation of China) Nos. 82470062, 82170046, 82100047, and 82300050
6 · The paper itself

Abstract

objectiveTo investigate the prevalence of depression and anxiety in interstitial lung disease (ILD) and reveal whether ILD is causally associated with depression and anxiety via Mendelian randomization (MR).

methodsEligible studies were identified and selected from Web of Science, PubMed and Scopus. The pooled prevalence of depression and anxiety in ILD, as well as the clinical characteristics of ILD with depression or anxiety, were assessed. Sensitivity analyses, subgroup analyses and meta-regression were applied for heterogeneity assessments. Data of MR analysis were derived from the UK biobank and Finngen cohort, and the inverse variance weighting approach was selected as the main approach for causality evaluation.

resultsA total of 35 studies were included in this meta-analysis, with 34 studies reporting depression in ILD and 21 reporting anxiety in ILD. The pooled prevalence of depression and anxiety in ILD were 22% (95% CI 17%, 26%, I

conclusionAlthough the prevalence of depression and anxiety were high in patients with ILD, no causal relationship was observed. Future studies are needed to investigate the intricate association between ILD and mental health.

Indexed as

AnxietyDepressionLung Diseases, InterstitialHumansMendelian Randomization AnalysisPrevalence

Identifiers

PMID41680136
PMCPMC12923813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.