Evidence map›Paper›PMID 41680078›Full record

ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2026

Epithelial-Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer.

Nicole Lonni, Camilla Kammer Pereira, Amanda Maciel Costa, Aline Hsiao Bona, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Elena Riet Correa Rivero

Abstract read
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In one paragraph

Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole LonniHealth Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0000-0002-5577-0294
Camilla Kammer PereiraHealth Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0009-0006-6990-9070
Amanda Maciel CostaHealth Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0009-0003-8016-0951
Aline Hsiao BonaHealth Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0009-0002-5960-1217
Andressa Fernanda Paza MiguelHealth Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0000-0003-4922-4809
Elis Ângela BatistellaCollege of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.ORCID https://orcid.org/0000-0002-0158-5085
Daniella Serafin Couto VieiraDepartment of Pathology, Health Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0000-0003-0188-6010
Elena Riet Correa RiveroDepartment of Pathology, Health Sciences Center, Federal University of Santa Catarina, SC, Brazil.ORCID https://orcid.org/0000-0002-8516-8771

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305891/2024-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 403444/2023-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

aimThis retrospective study investigates the interplay between epithelial-mesenchymal transition (EMT) and immune response within the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC). METHODOLOGY: Immunohistochemistry was conducted on OSCC specimens to evaluate the expression of podoplanin (PDP), E-cadherin (CDH1), vimentin (VIM), fibronectin (FN), tenascin-C (TNC), and vascular endothelial growth factor (VEGF). Cancer-associated fibroblasts (CAFs) were identified by alpha-smooth muscle actin (α-SMA), and immune cells were quantified using CD66b for neutrophils and CD8 for T lymphocytes.

resultsHigher α-SMA and moderate-to-strong VEGF expression were associated with reduced CDH1 and increased VIM and PDP expression (p < 0.05), indicating an EMT-like phenotype. Cases with elevated PDP-also linked to high α-SMA-showed increased CD66b

conclusionThese exploratory findings suggest that CAFs serve not only as a marker of stromal activation but may also contribute to immunomodulation and invasive tumor phenotype.

Indexed as

Carcinoma, Squamous CellEpithelial-Mesenchymal TransitionExtracellular MatrixMouth NeoplasmsActinsAdultAgedAntigens, CDCadherinsCancer-Associated FibroblastsCell Adhesion MoleculesFemaleFibronectinsHumansMaleMembrane GlycoproteinsACTA2 protein, humanActinsAntigens, CDCadherinsCell Adhesion MoleculesFibronectinsMembrane GlycoproteinsPDPN protein, humanPodoplaninTenascinVascular Endothelial Growth Factor AVimentincancer‐associated fibroblastsepithelial‐mesenchymal transitionimmunohistochemistryoral squamous cell carcinomatumor microenvironment

Identifiers

PMID41680078
PMCPMC13333532

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.