Evidence map›Paper›PMID 41680076›Full record

ArticleClinical and experimental pharmacology & physiology2026

Acupuncture Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through the IRP2/IRE Pathway.

Jia Yuan, Litong Chen, Qianjun Li, Rongqi Wei, Xiaoyue Liu, Chutao Chen, Haomei Tian

Abstract read
In one paragraph

Article in Clinical and experimental pharmacology & physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia YuanCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.ORCID 0009-0001-5499-5862
Litong ChenCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Qianjun LiCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Rongqi WeiCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Xiaoyue LiuCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Chutao ChenCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.
Haomei TianCollege of Acupuncture-Moxibustion-Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.

Funding

Hunan Provincial Traditional Chinese Medicine Research Program A2024009the National Natural Science Foundation of China 82274662the Natural Science Foundation of Hunan Province 2024JJ5305
6 · The paper itself

Abstract

Acupuncture (AC) has been demonstrated to improve outcomes in ischemic stroke. However, its precise mechanism of action remains incompletely understood. This study investigated the effects of AC in a rat model of cerebral ischemia-reperfusion injury (CIRI). A middle cerebral artery occlusion/reperfusion (MCAO/R) model was established to create CIRI rats. Rats were randomly assigned to the Sham, MCAO/R, AC + MCAO/R, IRP2

Indexed as

Acupuncture TherapyBrain IschemiaFerroptosisIron Regulatory Protein 2Reperfusion InjurySignal TransductionAnimalsInfarction, Middle Cerebral ArteryMaleNeuronsRatsRats, Sprague-DawleyReactive Oxygen SpeciesIron Regulatory Protein 2Reactive Oxygen Speciesacupuncturebrain ischemiaferroptosisIRP2/IREreperfusion injury

Identifiers

PMID41680076
PMCPMC12900629

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.