Evidence map›Paper›PMID 41679918›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Imaging Microtubule Dynamics In Vivo in Human Brain: Optimal Quantification Based on a Test-Retest Study.

Francesca Zanderigo, Gjertrud L Laurell, Mikhail Doubrovin, Andrei Molotkov, Alessandra Ali, Rodolfo F Arevalo, Kiran K Solingapuram Sai, J John Mann, Akiva Mintz

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca ZanderigoDepartment of Psychiatry, Columbia University, New York, New York; fz2173@cumc.columbia.edu francesca.zanderigo@gmail.com.
Gjertrud L LaurellDepartment of Psychiatry, Columbia University, New York, New York.
Mikhail DoubrovinDepartment of Radiology, Columbia University, New York, New York; and.
Andrei MolotkovDepartment of Radiology, Columbia University, New York, New York; and.
Alessandra AliDepartment of Radiology, Columbia University, New York, New York; and.
Rodolfo F ArevaloDepartment of Radiology, Columbia University, New York, New York; and.
Kiran K Solingapuram SaiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
J John MannDepartment of Psychiatry, Columbia University, New York, New York.
Akiva MintzDepartment of Psychiatry, Columbia University, New York, New York.

Funding

Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
A blood-brain-barrier permeable imaging biomarker for microtubules in the brain: A first-in-human clinical trialR21AG072570 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANN, JOSEPH JOHN, MINTZ, AKIVA · 2021 to 2022
$461k
NIA NIH HHS P30 AG072947NIA NIH HHS R21 AG072570
6 · The paper itself

Abstract

Microtubules are cytoskeletal components that play essential roles in the brain, including supporting neuronal structure, protein transport, and cognitive function. In vivo quantification of microtubule dynamics using PET is possible with

Indexed as

BrainMicrotubulesPositron-Emission TomographyAdultCarbon RadioisotopesFemaleHumansImage Processing, Computer-AssistedKineticsMalePyridinesPyrrolidinonesRadiopharmaceuticalsReproducibility of Results1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneCarbon RadioisotopesPyridinesPyrrolidinonesRadiopharmaceuticals11C-MPC6827microtubulesPETpharmacokinetic modelingrepeatability

Identifiers

PMID41679918
PMCPMC13041619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.