Evidence map›Paper›PMID 41679291›Full record

ReviewBritish journal of pharmacology2026

Only time will tell: Modelling the kinetics of covalent inhibitors.

Madeeha I Ali, Peter J Tonge

Abstract readReview
In one paragraph

Review in British journal of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. RSC chemical biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Madeeha I AliDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.
Peter J TongeDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.

Funding

Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR35GM149297 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PETER J TONGE · 2023 to 2026
$1.6M
NIGMS NIH HHS GM136572NIGMS NIH HHS GM149297NIGMS NIH HHS R35 GM149297NIGMS NIH HHS T32 GM136572
6 · The paper itself

Abstract

The selection and optimization of drug leads is largely driven by equilibrium parameters such as IC

Indexed as

binding kineticscovalent inhibitorirreversible inhibitionnon‐equilibriumslow‐onsettime‐dependent drug activity

Identifiers

PMID41679291
PMCPMC13234915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.