ArticlePoultry science2026
Anthelmintic effects of Artemisia herba-alba and Artemisia judaica extracts on Ascaridia galli in poultry.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Assessment of antiparasitic efficacy of Artemisia herba-alba and Artemisia judaica using in vitro, in silico, and animal-based models against Ascaridia galli was conducted. Ethanolic extracts from each Artemisia species were separately prepared in 0.5% DMSO. For the in vitro analysis, a total of 180 adult Ascaridia galli worms were harvested from naturally infected chicks and randomly assigned into four equal groups. Group 1 received Fenbendazole (0.5 mg/mL), Group 2 was treated with A. herba-alba extract (50 mg/mL), Group 3 with A. Judaica extract (50 mg/mL), and Group 4 served as the control, exposed to 0.5% DMSO. All treatments were applied for a duration of 13 hours. For the in vivo investigation, 540 A. galli-infected chicks were divided into six equally sized groups. Groups 1 and 2 received A. herba-alba at 1000 and 3000 mg/kg body weight, respectively. Similarly, Groups 3 and 4 were treated with A. Judaica at 1000 and 3000 mg/kg. Group 5 was administered Fenbendazole (50 mg/kg) as a positive control, while Group 6 served as the untreated control. Both A. herba-alba and A. Judaica significantly inhibited worm motility in vitro compared to the control group. Fenbendazole achieved 100% inhibition (P < 0.001), while A. herba-alba showed 30.1% inhibition (P < 0.05), and A. Judaica demonstrated 23.1% inhibition (P < 0.05). At 14 days post-treatment, Artemisia-treated groups showed a significant decrease in female fecundity, fecal egg count (FEC), and worm burden relative to the control group. Notably, there was no significant variation (P > 0.05) based on the Artemisia species or dose level used. In vitro exposure of nematodes to A. judaica and A. herba-alba extracts resulted in a significant, time-dependent reduction in worm motility compared with control treatments, whereas fenbendazole induced rapid and complete immobilization; no significant differences were observed between the two herbal extracts. Molecular docking analysis indicates that camphor demonstrated robust affinity score of -6.25 kcal/mol against ATP synthase, while camphor against glutathione transferase showed promising interactions with an affinity score of -6.90 kcal/mol. In conclusion, extracts of A. herba-alba and A. Judaica demonstrate significant potential as effective and suitable alternatives for managing A. galli infections in poultry by targeting ATP synthase and glutathione transferase in A. galli.
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