Evidence map›Paper›PMID 41678619›Full record

ArticleScience (New York, N.Y.)2026

Transcription factor Etv3 controls the tolerogenic function of dendritic cells.

Nicholas M Adams, Daniel Martinez-Krams, Eduardo Esteva, Ai C Ra, Allegra Iliadi Alexiou, Hua Jin, Tae Jin Yun, Rayan Sleiman Tellaoui, Tenny Mudianto, Emily Vollmer and 10 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nicholas M AdamsDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-5751-0480
Daniel Martinez-KramsDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-9731-605X
Eduardo EstevaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-7223-6632
Ai C RaApplied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0006-3161-113X
Allegra Iliadi AlexiouDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0007-9842-7852
Hua JinDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0001-8539-0006
Tae Jin YunDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-2728-7227
Rayan Sleiman TellaouiDepartment of Surgery, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0009-6528-2233
Tenny MudiantoRonald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.
Emily VollmerDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0009-5878-0752
Ekaterina NovikovaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0006-1501-1142
Yanjun TanDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
William HuntleyDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0009-0000-5405-2154
Oleg KrichevskyDepartment of Physics, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Igor DolgalevCellular Analytics Laboratory, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-4451-126X
Peter IzmirlyDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-5445-2182
Jill P BuyonDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-3852-7129
Andre L MoreiraDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-1857-3774
Amanda W LundDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-7389-9983
Boris ReizisDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-1140-7853

Funding

Translational Center of Molecular Profiling in Preclinical and Established Lupus (COMPEL)P50AR070591 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2017 to 2021
$6.7M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR37AI072571 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2018 to 2026
$5.3M
Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus ErythematosusR01AR071703 · NIAMS · UNIVERSITY OF CHICAGO · PI Jill P Buyon, GEORGE Georgiou GEORGIOU · 2018 to 2026
$4.4M
Chromatin architecture as a regulator of dendritic cell functionR01AI164728 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2022 to 2026
$2.7M
Molecular control of tolerogenic dendritic cell functionR21AI182549 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Amanda W. Lund · 2025 to 2026
$458k
NCCDPHP CDC HHS U01 DP006700NIAID NIH HHS R01 AI164728NIAID NIH HHS R21 AI182549NIAID NIH HHS R37 AI072571NIAMS NIH HHS P50 AR070591NIAMS NIH HHS R01 AR071703
6 · The paper itself

Abstract

Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-derived migratory DCs (migDCs), and facilitates their homeostatic maturation and CCR7-dependent migration. Mice with global or DC-specific deletion of Etv3 manifested the expansion of CD25

Indexed as

Dendritic CellsDNA-Binding ProteinsImmune ToleranceLupus Erythematosus, SystemicProto-Oncogene Proteins c-etsRepressor ProteinsTranscription FactorsAnimalsAutoimmunityCell DifferentiationCell MovementHumansLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred C57BLCcr7 protein, mouseDNA-Binding ProteinsETV3 protein, humanETV3 protein, mouseMembrane GlycoproteinsOX40 LigandProto-Oncogene Proteins c-etsReceptors, CCR7Repressor ProteinsTlr7 protein, mouseToll-Like Receptor 7Transcription Factors

Identifiers

PMID41678619
PMCPMC12977282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.