Evidence map›Paper›PMID 41678589›Full record

ArticlePLOS global public health2026

NTDscope: A multi-contrast portable microscope for disease diagnosis.

María Díaz de León Derby, Zaina L Moussa, Carlos F Ng, Abdul M Bhuiya, Joana P Cabrera, Dipayan Banik, Charles B Delahunt, Matthew D Keller, Anne-Laure M Le Ny, Jaime Garcia-Villena and 21 more

Abstract read
In one paragraph

Article in PLOS global public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

María Díaz de León DerbyDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0003-3080-7027
Zaina L MoussaDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0002-9166-7315
Carlos F NgDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0002-3760-6482
Abdul M BhuiyaDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0001-5209-7578
Joana P CabreraDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0001-5100-4560
Dipayan BanikGlobal Health Labs, Inc, Bellevue, Washington, United States of America.
Charles B DelahuntGlobal Health Labs, Inc, Bellevue, Washington, United States of America.ORCID https://orcid.org/0000-0003-4860-8069
Matthew D KellerGlobal Health Labs, Inc, Bellevue, Washington, United States of America.ORCID https://orcid.org/0000-0003-2081-6587
Anne-Laure M Le NyGlobal Health Labs, Inc, Bellevue, Washington, United States of America.ORCID https://orcid.org/0000-0002-0998-9375
Jaime Garcia-VillenaSpotlab, Madrid, Spain.ORCID https://orcid.org/0000-0002-4817-9279
Elena DacalSpotlab, Madrid, Spain.ORCID https://orcid.org/0000-0003-4599-0370
David Bermejo-PeláezSpotlab, Madrid, Spain.ORCID https://orcid.org/0000-0002-0181-3957
Daniel CuadradoSpotlab, Madrid, Spain.ORCID https://orcid.org/0000-0001-7216-0298
Miguel Luengo-OrozSpotlab, Madrid, Spain.ORCID https://orcid.org/0000-0002-8694-2001
Hugues C Nana DjeungaHigher Institute for Scientific and Medical Research (ISM), Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-4496-6048
Joseph KamgnoHigher Institute for Scientific and Medical Research (ISM), Yaoundé, Cameroon.ORCID https://orcid.org/0000-0003-1572-3490
Linda Djune YemeliHigher Institute for Scientific and Medical Research (ISM), Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-5098-6176
Victor PahlDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0009-0003-6643-8355
Saskia D DaviDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0009-0006-0027-0715
Rella Zoleko ManegoCentre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.ORCID https://orcid.org/0000-0001-7425-2794
Michael RamharterDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-9259-1885
Isaac I BogochDivision of General Internal Medicine, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1590-6748
Jean T CoulibalyUFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.
Amena KhatunInfections Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-4986-6396
Mamun KabirInfections Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Zannatun NoorInfections Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-9431-358X
Rashidul HaqueInfections Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0001-5100-136X
Neil A SwitzSan José State University, San José, California, United States of America.ORCID https://orcid.org/0000-0002-3639-4588
Daniel H FriedmanDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.
Michael V D'AmbrosioDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0009-0003-1061-2916
Daniel A FletcherDepartment of Bioengineering, University of California, Berkeley, Berkeley, California, United States of America.ORCID https://orcid.org/0000-0002-1890-5364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate diagnostics are essential for disease control and elimination efforts. However, access to diagnostics for neglected tropical diseases (NTDs) is hindered by limited healthcare infrastructure in many NTD-endemic regions, as well as by reliance on time- and labor-intensive diagnostic methods, such as smear microscopy. New diagnostic tools that are portable, rapid, low-cost, and meet World Health Organization (WHO) sensitivity and specificity targets are urgently needed to accelerate NTD control and elimination programs. Here, we introduce the NTDscope, a portable microscopy platform that enables point-of-care imaging and automated detection of parasites and other pathogens in patient samples. The NTDscope builds on and extends the capabilities of the LoaScope, a device that turned the camera of a mobile phone into a microscope and used on-board image processing to automatically quantify Loa loa microfilariae burden in whole blood samples. The NTDscope replaces the mobile phone of the LoaScope with a system-on-module (SOM) that enables the integration of multiple imaging modalities in a single package designed to improve robustness and expand applications. In this work, we demonstrate the use of the NTDscope as a portable brightfield, darkfield, and fluorescence microscope for samples including microfilariae and helminth eggs. We also show that the device can be used to quantify molecular assays, such as a lateral flow test and a CRISPR-Cas13a-based assay. The ability to combine the diagnostic capabilities of conventional microscopy with molecular assays and machine learning in a single device could expand access to diagnostics for populations in NTD-endemic areas and beyond.

Identifiers

PMID41678589
PMCPMC12900437

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.