Evidence map›Paper›PMID 41678438›Full record

ArticlePLoS biology2026

Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.

Yan Tao, Yuxin Zhao, Wenqi Zhong, Jiajia Zhang, Hongyan Zhu, Xutao Zhu, Zikun Wang, Na Wang, Liqin Yang, Fuqiang Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yan TaoShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Yuxin ZhaoShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Wenqi ZhongShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Jiajia ZhangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Hongyan ZhuShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Xutao ZhuShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Zikun WangShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Na WangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Liqin YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Fuqiang XuShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ruiqi WuShanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6333-0862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systematic identification of global epileptic reorganization and critical seizure-controlling circuits is essential for comprehending epilepsy pathophysiology and for developing network-guided targeted therapies. The piriform cortex (PC) is a recognized epileptogenic region, but how its hyperactivity reshapes whole-brain dynamics and which specific circuits mediate seizures remains unclear. Through multimodal integration of optogenetics, fMRI, electrophysiology, Ca2+ imaging, neural tracing, and circuit-specific manipulation, we mapped the whole-brain dynamics following optogenetic stimulation of PC and identified the fundamental circuit governing piriform seizures. We observed pronounced generalized seizures in mice via repeated optogenetic stimulation of PC Vglut1+ neurons. Optogenetic kindling of PCVglut1 induced widespread blood-oxygen-level-dependent (BOLD) signal hyperactivation and resting-state functional connectivity (rsFC) alterations, notably sustained hyperactivation in the lateral entorhinal cortex (Lent) and enhanced PC-Lent rsFC. Chronic elimination of Lent neurons receiving PC projections significantly decreased the Lent-dentate gyrus (DG) rsFC. Disruption of the PC-Lent or Lent-DG circuit effectively suppressed PC-stimulation-triggered seizures and brain-wide hyperactivation. Our findings demonstrate the dominant role of the PCVglut1-Lentglut-DG circuit in mediating piriform seizures and driving their resulting brain-wide functional reorganization, offering new insights for targeted epilepsy treatments.

Indexed as

Entorhinal CortexPiriform CortexSeizuresAnimalsBrainEpilepsyKindling, NeurologicMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLNeuronsOptogenetics

Identifiers

PMID41678438
PMCPMC12900355

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.