ArticleCell reports2026
Tfam-mediated metabolic perturbation in RORγt
Na Sun, Rupam Paul, Eric Y Helm, Zong-Ming E Chen, John W Bostick, Liang Zhou
Abstract read
In one paragraphArticle in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Na SunDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, Gainesville, FL 32608, USA.
Rupam PaulDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, Gainesville, FL 32608, USA.
Eric Y HelmDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, Gainesville, FL 32608, USA.
Zong-Ming E ChenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
John W BostickDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, Gainesville, FL 32608, USA.
Liang ZhouDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, Gainesville, FL 32608, USA; Center for Inflammation and Mucosal Immunology, University of Florida, Gainesville, FL 32608, USA. Electronic address: liangzhou497@ufl.edu.
Funding
Regulation of Gut Innate Lymphoid Cells by AhrR01AI132391 · NIAID · UNIVERSITY OF FLORIDA · PI Liang Zhou · 2017 to 2026
$4.8MRole of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue HomeostasisR01AI157109 · NIAID · UNIVERSITY OF FLORIDA · PI ZHOU, LIANG · 2021 to 2025
$2.8MNIAID NIH HHS R01 AI132391NIAID NIH HHS R01 AI157109
6 · The paper itselfAbstract
Rorc-mediated deletion of Tfam, a mitochondrial transcription factor, causes tuft cell and type 2 immunity-driven small intestine (SI) lengthening in mice. Here, we report an indispensable role for T helper 2 (Th2) cells in this process. High-fat diet (HFD) reverts SI lengthening in Tfam
Indexed as
DNA-Binding ProteinsGATA3 Transcription FactorHigh Mobility Group ProteinsHomeostasisImmunity, InnateIntestinesLymphocytesMitochondrial ProteinsNuclear Receptor Subfamily 1, Group F, Member 3Transcription FactorsAnimalsColitisDiet, High-FatIntestine, SmallMiceMice, Inbred C57BLDNA-Binding ProteinsGata3 protein, mouseGATA3 Transcription FactorHigh Mobility Group ProteinsMitochondrial ProteinsNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mouseTfam protein, mouseTranscription FactorscolitisCP: immunologyCP: metabolismhigh-fat dietILCsmetabolic dysfunctionsmall intestine lengtheningTfam
Identifiers
PMID41678335
PMCPMC13232894
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