Evidence map›Paper›PMID 41678081›Full record

ArticleJournal of computational neuroscience2026

A next generation neural mass model with neuromodulation.

Damien Depannemaecker, Chloé Duprat, Gabriele Casagrande, Marisa Saggio, Anastasios Polykarpos Athanasiadis, Marianna Angiolelli, Carola Sales Carbonell, Huifang Wang, Spase Petkoski, Pierpaolo Sorrentino and 3 more

Abstract read
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In one paragraph

Article in Journal of computational neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The Virtual Parkinsonian patient.NPJ systems biology and applications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Damien DepannemaeckerAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France. damien.depannemaecker@univ-amu.fr.
Chloé DupratAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Gabriele CasagrandeAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Marisa SaggioAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Anastasios Polykarpos AthanasiadisAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Marianna AngiolelliAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Carola Sales CarbonellAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Huifang WangAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Spase PetkoskiAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Pierpaolo SorrentinoAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Anthony Randal McIntoshSimon Fraser University, Vancouver, British Columbia, Canada.
Hiba SheheitliAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Viktor JirsaAix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France. viktor.jirsa@univ-amu.fr.

Funding

AMidex, a French "Investissements d'Avenir programme" AMX-21-IET-017Canada's New Frontiers in Research Fund (NFRF) SFUEU's Horizon Europe Programme SGA 101137289 (Virtual Brain Twin) SGA 101137289EU's Horizon Europe Programme SGA 101147319 (EBRAINS 2.0) SGA 101147319
6 · The paper itself

Abstract

The study of brain activity and its function requires the development of computational models alongside experimental investigations to explore different effects of multiple mechanisms at play in the central nervous system. Chemical neuromodulators, such as dopamine, play central roles in regulating the dynamics of neuronal populations. In this work, we propose a modular framework to capture the effects of neuromodulators at the neural mass level. Using this framework, we formulate a specific model for dopamine dynamics affecting D1-type receptors. We detail the dynamical repertoire associated with dopamine concentration evolution and characterize the transitions across qualitatively different oscillatory states as a function of relevant parameters, along with the variations in frequency of the emergent multi-scale oscillations.

Indexed as

BrainDopamineModels, NeurologicalNeuronsNeurotransmitter AgentsAnimalsComputer SimulationHumansReceptors, Dopamine D1DopamineNeurotransmitter AgentsReceptors, Dopamine D1DopamineMean-fieldNeural mass modelNeuromodulation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.