ReviewJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Idiopathic hypersomnia is a 24-hour disorder.
Review in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Novel Compounds as Orexin 2 Receptor Agonists for Treating Narcolepsy.ACS medicinal chemistry letters · 2026Article
- Novel 3‑Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia.ACS medicinal chemistry letters · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic hypersomnia is a heterogeneous disorder with daytime and nighttime symptoms that have a profound 24-hour effect on individuals' well-being. Daytime signs and symptoms include excessive daytime sleepiness, unrefreshing naps, autonomic dysfunction, fatigue, and brain fog; nighttime signs and symptoms include long sleep, and sleep inertia. Symptom overlap between idiopathic hypersomnia and narcolepsy type 2 and the varied disease course of idiopathic hypersomnia present challenges in diagnosis. Furthermore, the diagnostic criteria for idiopathic hypersomnia are inadequate in their current form, and their use can lead to misdiagnosis and suboptimal treatment. The unclear pathophysiology of idiopathic hypersomnia and the absence of reliable biomarkers necessitate careful use of a variety of tests to make an accurate diagnosis. The Idiopathic Hypersomnia Severity Scale captures symptoms that distinguish idiopathic hypersomnia from narcolepsy, but this scale requires further evaluation in real-world populations and should be used with objective measures of sleep parameters and other validated instruments to accurately capture the full range of symptoms over a 24-hour period. This review describes a holistic view of the symptoms and impact of idiopathic hypersomnia, and frames diagnostic challenges and treatment considerations within the context of this view. Expert clinical opinion that aims to improve the diagnostic accuracy and treatment of idiopathic hypersomnia is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.