Observational studyEsophagus : official journal of the Japan Esophageal Society2026
Lack of predictive value of esophageal multiple lugol-voiding lesions for metachronous head and neck cancer in patients undergoing transoral surgery for superficial hypopharyngeal cancer.
Observational study in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of multiple Lugol-voiding lesions (LVLs) in the esophagus and pharynx is indicative of an increased risk for metachronous cancer. However, it is unclear whether esophageal LVLs can predict the development of head and neck squamous cell carcinoma (HNSCC).
methodsThis retrospective observational study focused on patients who underwent transoral surgery for hypopharyngeal squamous cell carcinoma. Endoscopic images were categorized into three groups based on the number of unstained lesions in the pharyngeal mucosa: Group A had no lesions, Group B had 1 to 4 lesions, and Group C had 5 or more lesions per endoscopic view. Similarly, esophageal unstained lesions were classified into three groups based on the number of Lugol-unstained lesions: Group A had no lesions, Group B had 1 to 9 lesions, and Group C had 10 or more lesions.
resultsA total of 313 patients were included in the study. Among them, 157 patients (50.2%) had matching grades between pharyngeal and esophageal LVLs. The concordance between esophageal and pharyngeal LVL grades was weak (κ = 0.21, 95% confidence interval [CI]: 0.125-0.295, p < 0.001). The 3-, 5-, and 10-year cumulative incidences of metachronous HNSCC in esophageal LVL grades A, B, and C were 25.9%, 23.2%, and 21.5%; 35.2%, 33.2%, and 33.2%; and 51.4%, 48.6%, and 52.0%, respectively (log-rank test, p = 0.99). In a multivariate Cox regression analysis, esophageal LVL grade was not significantly associated with the development of metachronous HNSCC (hazard ratio: 0.76, 95% CI: 0.51-1.14, p = 0.182).
conclusionsPharyngeal, rather than esophageal, LVLs serve as a more reliable indicator of metachronous HNSCC risk in patients with primary hypopharyngeal cancer.
Indexed as
Identifiers
41678054What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.