Evidence map›Paper›PMID 41677995›Full record

SynthesisInternational ophthalmology2026

Comparing widefield and ultra-widefield optical coherence tomography angiography with fluorescein angiography in diabetic retinopathy: a review.

Parva Pourbagherkhah, Hemn Baghban Jaldian

Abstract readSystematic ReviewComparative Study
PubMed Publisher
In one paragraph

Synthesis in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Parva PourbagherkhahDepartment of Optometry, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-5417-3383
Hemn Baghban JaldianDepartment of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hemnbaghban19@gmail.com.ORCID http://orcid.org/0000-0002-5136-3843

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetic retinopathy (DR) is a major cause of vision impairment worldwide. Widefield optical coherence tomography angiography (WF-OCTA) is a non-invasive alternative to widefield fluorescein angiography (WF-FA) that provides high-resolution imaging of retinal vasculature. This systematic review evaluates the diagnostic performance of WF-FA and ultra-widefield (UWF)-FA vs. WF-OCTA and UWF-OCTA in detecting DR-related retinal vascular changes.

methodsA systematic search was conducted, following PRISMA guidelines. Studies reporting quantitative or qualitative findings on microaneurysms (MAs), intra-retinal microvascular abnormalities (IRMAs), and neovascularization (NV), or foveal avascular zone (FAZ) changes were analyzed.

resultsA total of 12 studies (648 eyes) met the inclusion criteria. Findings suggest that WF-OCTA detect NV with high sensitivity (96.55%) and specificity (94.74%), comparable to WF-FA. However, WF-FA showed potential in certain qualitative aspects, suggesting a possible complementary role.

conclusionWF-OCTA and UWF-OCTA are promising non-invasive alternatives to WF-FA and UWF-FA, offering high diagnostic accuracy, rapid imaging, and depth-resolved vascular analysis.

Indexed as

Diabetic RetinopathyFluorescein AngiographyRetinal VesselsTomography, Optical CoherenceFundus OculiHumansDiabetic retinopathyMacular microvasculatureRetinal imagingWide-field fluorescein angiographyWide-field optical coherence tomography angiography

Identifiers

PMID41677995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.