ArticleWorld journal of urology2026
Dynamic 18 F-PSMA-1007 PET-CT kinetics as a prognostic marker in newly diagnosed prostate cancer: a prospective pilot study.
Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProstate cancer remains a leading cause of cancer-related morbidity and mortality among men worldwide. Recent advances in molecular imaging, particularly Prostate-Specific Membrane Antigen labelled (PSMA) PET-CT, offers more robust diagnostic accuracy over conventional imaging with information regarding actual disease burden.
objectiveThis study evaluates the diagnostic and prognostic significance of dynamic PSMA PET-CT parameters, focusing on time-activity curve (TAC) patterns in newly diagnosed prostate cancer patients.
methodsA prospective single-arm study was conducted at a tertiary care center in India, involving 29 patients with histologically confirmed, untreated prostate adenocarcinoma. They underwent dynamic pelvic PSMA-1007 PET-CT followed by delayed whole-body 18 F-PSMA-1007 PET-CT scans. The time-activity curves (TACs) were generated from dynamic imaging and categorized into early and late crossing based on a 15-minute threshold limit. Patients were stratified by CHAARTED criteria (disease volume), Gleason score, and Serum PSA levels. Statistical analysis included t-tests, chi-square tests, regression analysis, and correlation studies.
resultsEarly TAC crossing was found in 69% of patients and was significantly associated with high disease volume (100%, p = 0.001) and higher serum PSA (p = 0.003). Late crossing patterns correlated with lower disease burden and 100% survival. Gleason score did not show any significant correlation with the disease volume or survival outcomes. TAC pattern was an independent predictor of disease volume (p < 0.0001).
conclusionDynamic PSMA PET-CT imaging can prove to be a significant tool for diagnosis and prognostication of newly diagnosed case of prostate cancer. Early crossing TAC patterns indicate more aggressive disease and overall poor prognosis.
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