Evidence map›Paper›PMID 41677889›Full record

ArticleEuropean journal of nutrition2026

Comparative peptidomic profile and bioactivities of Pacific oyster, Mytilus edulis, Argopecten irradians, Meretrix meretrix L. after simulated gastrointestinal digestion.

Kaiyue Liu, Na Li, Jiayi Fan, Siliang He, Weixiang Tang, Yaxin Cao, Liang Shen, Shuyang Sun, Chengcheng Du, Chao Du

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaiyue LiuSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Na LiSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Jiayi FanSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Siliang HeSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Weixiang TangSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Yaxin CaoSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Liang ShenSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Shuyang SunSchool of Food Engineering, Ludong University, Yantai, People's Republic of China.
Chengcheng DuDepartment of Biology, Duke University, Durham, NC, 27708, USA.
Chao DuSchool of Food Engineering, Ludong University, Yantai, People's Republic of China. ruindu@163.com.

Funding

National Natural Science Foundation of China No. 32272281Natural Science Foundation of Shandong Province, China No. ZR2020QC239Youth Innovation Technology Project of Higher School in Shandong Province Food Nanotechnology innovation team
6 · The paper itself

Abstract

purposeThis study investigated the basic composition, in vitro digestibility, biological activities, and potential bioactive peptides of Pacific oyster (PO), Mytilus edulis (ME), Argopecten irradians (AIS), and Meretrix meretrix L. (MML) after simulated gastrointestinal digestion (SGD).

methodsSGD products were prepared using the INFOGEST 2.0 model, and their nutritional properties and biological activities were analyzed. A comprehensive peptidomic profiling of the digested samples was conducted using nano-liquid chromatography-tandem mass spectrometry (nano-LC MS/MS) analysis.

resultsAll four shellfish exhibited a nutritional profile characterized by high protein and low-fat content. The digestibility of shellfish increased progressively, while the average molecular weight (MW) of the hydrolysates gradually decreased during SGD, with the intestinal hydrolysates showing the highest overall digestibility. Biological activity analysis demonstrated that intestinal digestion products from all four species exhibited notable ABTS radical scavenging activity and α-glucosidase inhibition activity, with PO and ME exhibiting the strongest effects. A total of 349, 99, 314 and 105peptides were identified from the digestion products of PO, ME, AIS, and MML, respectively. Among these, PO and AIS showed the highest sequence similarity, sharing 69 identical peptides. By contrast, MML displayed distinct peptidomic characteristics, including a higher proportion of large MW peptides.

conclusionThis study provides a comprehensive peptide catalog of shellfish digestion products and offers new insights into the biological activities of shellfish-derived peptides, supporting their potential as functional food resources.

Indexed as

DigestionMytilus edulisOstreidaePeptidesShellfishShellfish ProteinsAnimalsBioactive Peptides, DietaryChromatography, LiquidGastrointestinal TractGastropodaGlycoside Hydrolase InhibitorsMolecular WeightTandem Mass SpectrometryBioactive Peptides, DietaryGlycoside Hydrolase InhibitorsPeptidesShellfish ProteinsBiological activityNutritional propertiesPeptidomicsShellfishSimulated gastrointestinal digestion

Identifiers

PMID41677889

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.