ArticleCancer immunology, immunotherapy : CII2026
Rituximab for severe immune checkpoint inhibitor-related adverse events: a multicenter case series.
Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmune checkpoint inhibitors (ICIs) can induce severe immune-related adverse events (irAEs) that are life-threatening and may be refractory to standard immunosuppressive therapy. Rituximab has emerged as a potential treatment option, but evidence is limited.
methodsWe conducted a retrospective multicenter study including patients who received rituximab for severe ICI-related irAEs between 2018 and 2023. Clinical characteristics, type and severity of irAEs, previous immunosuppressive regimens, outcomes after rituximab, and oncologic status were collected. Overall survival was estimated from rituximab initiation.
resultsEighteen patients were identified (median age 66 years, 55% male). irAEs were mainly neurological syndromes (n = 7), myositis and myocarditis (n = 6), and interstitial lung disease (n = 3). All events were grade 3-4 according to common terminology criteria for adverse events v5.0 and refractory to corticosteroids, often combined with additional immunosuppressants. Rituximab was administered as second- or third-line therapy. Clinical improvement was observed in 83% of patients, including complete resolution in 39%. After a median follow-up from rituximab initiation of 9.7 months (interquartile range [IQR] 5.1-23.9), seven patients (39%) died, but due to irAE only for three patients (17%).
conclusionsRituximab appears to be an effective therapeutic option for selected severe ICI-related irAEs, particularly when conventional immunosuppressive regimens fail. These real-world data highlight the potential role of B-cell-targeted therapy in the management of complex irAEs and support further evaluation in prospective studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.