ArticleJournal of bone and mineral metabolism2026
How postmenopausal osteoporosis influences epidemiology and clinical features of CRPS-1.
Article in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
introductionThis study aimed to investigate the relationship between Osteoporosis (OP) and Complex Regional Pain Syndrome type 1 (CRPS-1), in the hypothesis that OP can influence the epidemiological and clinical features of CRPS-1. MATERIALS AND
methodsFrom March 2013 to May 2024, consecutive patients newly diagnosed with CRPS-1 were recruited. Demographic and clinical variables were collected in a standardised fashion. Univariate analyses and multivariate linear regression models were used to investigate the sample.
resultsWe enrolled 425 patients, mostly females (70.1%), more than half (52.2%) with a fracture as the inciting event. A previous OP diagnosis was found in 113 patients (26.6%). Variables significantly associated with OP were female gender, hand localisation, fracture as the inciting event, and a more severe CRPS-1. A fracture in patients with OP seems to trigger CRPS-1 mainly in women in the first decade after menopause, while in males and in older women a weaker association was observed. Multivariate analysis showed a correlation between OP and a more severe CRPS-1 (p = 0.014).
conclusionA higher incidence of OP was observed more frequently in women with CRPS-1 in the first decade after menopause. This result could be driven by the proinflammatory cytokines increase observed in the early menopause, inducing both a faster systemic bone loss and an "inflammatory milieu" acting as a predisposing factor for CRPS-1 onset and a more severe disease.
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