Evidence map›Paper›PMID 41677825›Full record

SynthesisEuropean archives of psychiatry and clinical neuroscience2026

Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.

Giulia Maria Giordano, Giulia Cattarinussi, Andrew Lawrence, Nare Amasi-Hartoonian, Svenja Kretzer, Xuemei Ma, Rebecca Pollard, Corentin Vallée, Armida Mucci, Silvana Galderisi and 1 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giulia Maria GiordanoDepartment of Mental and Physical Health and Preventive Medicine, School of Medicine, University of Campania Luigi Vanvitelli, Largo Madonna delle Grazie 1, 80135, Naples, Italy. giuliamaria.giordano@unicampania.it.ORCID http://orcid.org/0000-0002-5247-1117
Giulia CattarinussiDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Andrew LawrenceDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Nare Amasi-HartoonianDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Svenja KretzerDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Xuemei MaDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Rebecca PollardDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Corentin ValléeDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Armida MucciDepartment of Mental and Physical Health and Preventive Medicine, School of Medicine, University of Campania Luigi Vanvitelli, Largo Madonna delle Grazie 1, 80135, Naples, Italy.
Silvana GalderisiDepartment of Mental and Physical Health and Preventive Medicine, School of Medicine, University of Campania Luigi Vanvitelli, Largo Madonna delle Grazie 1, 80135, Naples, Italy.
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse childhood experiences (ACEs), which include potentially traumatic events occurring during childhood, have been found to be associated with alterations in resting-state functional connectivity (rs-FC) within large brain networks, such as the Salience (SN), Default Mode (DMN), and Central Executive (CEN) Networks. While alterations in these networks may increase vulnerability to mental health disorders, existing data are inconsistent as to the neural pathways affected and the type of connectivity pattern associated with adversity (hyper- or hypoconnectivity). These inconsistencies could be due to methodological differences across studies, to the selection of different target regions of interest (ROIs), or to the use of ROI-to-ROI approaches that could overlook broader effects at the whole-brain level. Here, we conducted a meta-analysis of rs-FC seed-to-whole brain studies using the Seed-based d Mapping software to investigate patterns of rs-FC aberrations specifically associated with ACEs. Out of 12 identified studies, eight were included in the meta-analysis, comprising 289 individuals positive for ACEs and 301 controls. The analysis showed that individuals positive for ACEs, compared to controls, present a pattern of hypoconnectivity centred within the SN, between SN and DMN integrative hubs, and between DMN and CEN. Such disruptions, potentially resulting from prolonged or excessive activity of the hypothalamus-pituitary-adrenal axis, might affect emotion regulation, fear conditioning, memory and affective learning processing, goal-directed behavior, and cognitive control, and increase vulnerability to mental health disorders. Future research should focus on more homogeneous populations and larger samples, to truly advance our understanding of the biological mechanisms underlying ACEs-related brain connectivity disruptions.

Indexed as

Adverse Childhood ExperiencesBrainCerebral CortexConnectomeDefault Mode NetworkNerve NetHumansMagnetic Resonance ImagingACEsAdverse childhood experiencesMeta-analysisResting-state functional connectivityrs-fMRI

Identifiers

PMID41677825
PMCPMC13233943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.