ReviewNaunyn-Schmiedeberg's archives of pharmacology2026
RAW 264.7 macrophage cell line as a metabolomic model for analyzing and understanding inflammation processes.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of Rosifoliol/Agarospirol and 7α-Hydroxysandaracopimaric Acid fromMolecules (Basel, Switzerland) · 2026Article
- Chemical profiling of Egregia menziesii and anti-inflammatory potential in LPS-activated RAW 264.7 macrophages.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functionality of cellular models to provide relevant and functional information has been demonstrated. Several stimuli can result in intracellular changes that can be tracked through omics sciences, such as metabolomics, a valuable tool for characterizing and quantifying metabolic changes associated. RAW 264.7 macrophage cell line is a polarizable immune cell, making it a classic cellular model for the analysis of inflammatory processes, diverse stimuli provide an overview of the cell-stimulus interaction. Although the procedures for conducting a metabolomic study, from the collection of treated cells to the obtention of the data generated, have not yet become widespread, most research using this cell line indicates that there are common metabolites, and their variation in the metabolic pathways could be fundamental for performance and function of the immune cell. Thus, in this review, we describe the application of RAW 264.7 macrophages as a metabolomic model, highlighting the sample collection processes, commonly used analytical methods, software for data analysis, multivariate analysis used for the characterization of metabolites and how these changes can help to understand inflammatory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.