SMG6's PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD)

Baihui Chai, Xiao Tan, Yan Li, Chengyan Chen, Xin Ma, Tangliang Li

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Baihui ChaiState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.

Xiao TanState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.

Yan LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.

Chengyan ChenState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.

Xin MaState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.

Tangliang LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao Campus, Qingdao 266237, China.ORCID 0000-0003-0671-9166

Funding

Natural Science Foundation of Shandong Province ZR2023MC013, ZR2024QC193Postdoctoral Innovation Program of Shandong Province SDCX-ZG-202303003

6 · The paper itself

Abstract

Nonsense-mediated mRNA decay (NMD) is a highly conserved RNA quality and quantity surveillance machinery in eukaryotic cells, serving as an important node in the post-transcriptional gene expression. Previous studies using the complete knockout of individual NMD factors in cells or animals reveal that NMD deficiency causes developmental defects and compromises tissue homeostasis. However, because most NMD factors participate in multiple molecular functions, a direct link between NMD and cell fate determination is missing. SMG6 is a core NMD effector and the only endoribonuclease among all NMD factors. The NMD function of SMG6 is exclusively mediated by its PIN (PilT N-terminus) domain. In this study, we engineered a mouse model with the capability of specifically deactivating the SMG6's PIN domain/endoribonuclease activity (

Indexed as

Nonsense Mediated mRNA DecayAnimalsCell DifferentiationEmbryonic Stem CellsEndoribonucleasesMaleMiceMice, KnockoutMouse Embryonic Stem CellsProtein DomainsEndoribonucleasesdifferentiationembryonic stem cellPIN domainSMG6tissue homeostasis

Identifiers

PMID41677645

DOI10.3390/cells15030282

PMCPMC12896539

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LicenceCC BY

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