Evidence map›Paper›PMID 41677643›Full record

ArticleCells2026

Interleukin-38: A Candidate Biomarker for Disease Severity in Advanced Steatotic Liver Disease.

Valeria Wagner, Michael Mederer, Barbara Enrich, Veronika Cibulkova, Johanna Piater, Andreas Zollner, Rebecca Giquel-Fernandes, Herbert Tilg, Maria Effenberger

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valeria WagnerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.
Michael MedererDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.ORCID 0009-0004-5901-624X
Barbara EnrichDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.
Veronika CibulkovaDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.ORCID 0009-0007-5416-7841
Johanna PiaterDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.
Andreas ZollnerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.ORCID 0000-0001-6095-068X
Rebecca Giquel-FernandesDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.ORCID 0000-0002-4235-2579
Maria EffenbergerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Christoph-Probst-Platz 1, 6020 Innsbruck, Austria.ORCID 0000-0002-0499-9953

Funding

Austrian Society of Gastroenterology and Hepatology Nachwuchswisschenschaftspreis 2025Austrian Society of Gastroenterology and Hepatology Wissenschaftspreis 2022Landes Tirols AI in Medicine
6 · The paper itself

Abstract

backgroundInterleukin-38 (IL-38) is an anti-inflammatory IL-1-family cytokine implicated in limiting tissue injury by its anti-inflammatory character. We evaluated the diagnostic discrimination and prognostic relevance in steatotic liver disease (SLD).

methodsWe conducted a prospective, monocentric cohort analysis of 184 patients with SLD (

findingsIL-38 concentrations were found to be higher in decompensated (

conclusionIL-38 reflects the severity of steatotic liver disease and is therefore a potentially predictive biomarker for early risk stratification and therapy monitoring.

Indexed as

BiomarkersFatty LiverInterleukinsAdultAgedFemaleHumansMaleMiddle AgedPrognosisProspective StudiesROC CurveSeverity of Illness IndexBiomarkersIL-38 protein, humanInterleukinsalcohol-associated liver disease (ALD)biomarkerhepatic decompensationIL-1 cytokine familyIL-38metabolic dysfunction-associated alcohol-related liver disease (metALD)

Identifiers

PMID41677643
PMCPMC12897045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.