Evidence map›Paper›PMID 41677594›Full record

ArticleCells2026

Phenylketonuria Alters the Prefrontal Cortex Genome-Wide Expression Profile Regardless of the Mouse Genetic Background.

Elena Fiori, Serafina Manila Guzzo, Luisa Lo Iacono, Cristina Orsini, Simona Cabib, Diego Andolina, Luigia Rossi, Francesca Nardecchia, Vincenzo Leuzzi, Tiziana Pascucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena FioriTechnopole Foundation, 00185 Rome, Italy.ORCID 0000-0003-2990-9624
Serafina Manila GuzzoDepartment of Psychology, Centro "Daniel Bovet", Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-6120-2824
Luisa Lo IaconoDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2979-6957
Cristina OrsiniDepartment of Psychology, Centro "Daniel Bovet", Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-1280-3233
Simona CabibFondazione Santa Lucia Istituto di Ricovero e Cura a Carattere Scientifico, 00143 Rome, Italy.
Diego AndolinaDepartment of Psychology, Centro "Daniel Bovet", Sapienza University, 00185 Rome, Italy.
Luigia RossiDepartment of Biomolecular Science, University of Urbino, 61029 Urbino, Italy.
Francesca NardecchiaUnit of Child Neurology and Psychiatry, Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0808-2827
Vincenzo LeuzziUnit of Child Neurology and Psychiatry, Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2314-6139
Tiziana PascucciDepartment of Psychology, Centro "Daniel Bovet", Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-1520-7373

Funding

Italian Health Ministry RF-2019-12369782
6 · The paper itself

Abstract

Mouse models of genetic diseases are important research tools. However, the genetic background of the mouse strain can significantly influence how a genetic mutation is expressed. Studies on preclinical models of phenylketonuria (PKU), an inherited metabolic disorder, have used two strains, BTBR and C57Bl/6, created via a chemically induced point mutation in the gene encoding the enzyme phenylalanine hydroxylase (BTBR

Indexed as

Genetic BackgroundPhenylketonuriasPrefrontal CortexTranscriptomeAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLPhenylalanine HydroxylasePhenylalanine Hydroxylaseattention and memoryHPA resilience and vulnerabilityphenylketonuriaprefrontal cortextranscriptome

Identifiers

PMID41677594
PMCPMC12896771

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.