Evidence map›Paper›PMID 41677586›Full record

ArticleCells2026

Reduced LOXL3 Expression Disrupts Microtubule Acetylation and Drives TP53-Dependent Cell Fate in Glioblastoma.

Talita de Sousa Laurentino, Roseli da Silva Soares, Antônio Marcondes Lerario, Ricardo Cesar Cintra, Suely Kazue Nagahashi Marie, Sueli Mieko Oba-Shinjo

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Talita de Sousa LaurentinoCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, SP, Brazil.ORCID 0000-0002-6279-0437
Roseli da Silva SoaresCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, SP, Brazil.
Antônio Marcondes LerarioDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8336-6432
Ricardo Cesar CintraCentro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo (ICESP), Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-5374-5319
Suely Kazue Nagahashi MarieCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, SP, Brazil.ORCID 0000-0003-4419-7928
Sueli Mieko Oba-ShinjoCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, SP, Brazil.ORCID 0000-0002-1650-5973

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo #2015/03614-5, #2016/05777-1, #2020/02988-9, #2021/01207-4National Council for Scientific and Technological Development #140482/2020-2, #304541/2020-6, #317214/2021-7, #312361/2025-4
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumor, marked by molecular heterogeneity and poor clinical prognosis. Lysyl oxidase-like 3 (LOXL3) is frequently upregulated in GBM, but its mechanistic contribution remains insufficiently defined. Here, we investigated the functional role of LOXL3 in GBM using CRISPR-Cas9-mediated LOXL3 knockdown in two genetically distinct GBM cell lines: U87MG (wild-type

Indexed as

Amino Acid OxidoreductasesBrain NeoplasmsGlioblastomaMicrotubulesTumor Suppressor Protein p53AcetylationApoptosisCell AdhesionCell Line, TumorCell MovementCell ProliferationCellular SenescenceGene Expression Regulation, NeoplasticHumansMitosisTubulinAmino Acid OxidoreductasesTP53 protein, humanTubulinTumor Suppressor Protein p53adhesionapoptosisglioblastomaLOXL3senescenceTP53

Identifiers

PMID41677586
PMCPMC12896791

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.