ArticleEpilepsia2026
Bidirectional sleep-seizure interactions and orexin in a mouse model of tuberous sclerosis complex-related epilepsy.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveA strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure-sleep interactions is poorly understood. In this study, we characterized the relationship between seizures and sleep in a mouse model of the genetic disorder tuberous sclerosis complex (TSC) and investigated potential mechanisms underlying seizure-sleep interactions related to hypothalamic orexin.
methodsTsc1
resultsOverall seizures occurred most commonly in non-REM sleep in Tsc1 SIGNIFICANCE: A bidirectional relationship between seizures and sleep was demonstrated in a mouse model of TSC, with relative seizure frequency surprisingly being highest in REM sleep and seizures causing a disruption of REM sleep. Hypothalamic orexin may partly mediate these seizure-sleep interactions, and orexin antagonists may represent rational therapies for sleep disorders in TSC.
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