Evidence map›Paper›PMID 41677452›Full record

ArticleRadiology. Cardiothoracic imaging2026

Rapid Visualization of Valves and Myocardium Using Volume Rendering of 3D Cardiac MRI, 4D Cine, and 4D Flow Images.

Julia Iacovella, Danish Vaiyani, Sehdev Pressley, Andras Lasso, Analise M Sulentic, Alana R Cianciulli, Ashley Koluda, Matthew Daemer, Mark A Fogel, Kevin K Whitehead and 1 more

Abstract read
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia Iacovella *Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0009-0003-9420-6770
Danish Vaiyani *Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pa.ORCID 0000-0003-2710-1779
Sehdev PressleyDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0009-0008-0792-0244
Andras LassoLaboratory for Percutaneous Surgery, School of Computing, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-4220-7064
Analise M SulenticDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0000-0003-2229-3134
Alana R CianciulliDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.
Ashley KoludaDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0009-0004-4860-4927
Matthew DaemerDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0009-0008-6059-8469
Mark A FogelDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Kevin K WhiteheadDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pa.ORCID 0000-0001-7343-7949
Matthew A JolleyDepartment of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.ORCID 0000-0002-5626-0130

Funding

Computer Modeling of the Tricuspid Valve in Hypoplastic Left Heart SyndromeR01HL153166 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOLLEY, MATTHEW · 2020 to 2024
$3.7M
NHLBI NIH HHS R01 HL153166
6 · The paper itself

Abstract

Purpose To develop a volume rendering method to visualize myocardial structures and blood flow using three-dimensional (3D), four-dimensional (4D) cine, and 4D flow cardiac MRI. Materials and Methods In this retrospective study, custom transfer functions for volume rendering and novel dense streamline-based 4D flow visualizations were developed and implemented in 3D Slicer, an open-source image computing platform. These techniques were applied to the cardiac MRI studies (April 2023 to January 2025) of four pediatric patients with congenital heart disease to inform comprehension of complex anatomy and to guide surgical repair. Results Applications are demonstrated in four patients (mean age, 4.5 years ± 1.1 [SD]; three female, one male), including integration into interventional planning workflows. Cardiac MRI enabled rapid and dynamic 3D and 4D visualization of the myocardium and valves in less than 1 second, with image refinement completed in less than 3 minutes. The integration of tissue rendering with 4D flow visualization allowed the simultaneous depiction of valve dynamics, regurgitation, and stenosis. Conclusion Volume rendering of the myocardium and cardiac valves in MRI studies enables rapid, dynamic visualization and can be feasibly applied in clinical settings. Integration with 4D flow visualization may improve the understanding of valve dysfunction and support procedural planning.

Indexed as

Heart Defects, CongenitalHeart ValvesImaging, Three-DimensionalMagnetic Resonance ImagingMagnetic Resonance Imaging, CineChild, PreschoolFemaleHumansMaleMyocardiumRetrospective StudiesHeartMR ImagingPediatricsValves

Identifiers

PMID41677452
PMCPMC12949417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.