Evidence map›Paper›PMID 41677440›Full record

ArticleOrganic letters2026

Room-Temperature Decarboxylative Amination of Electron-Deficient (Hetero)Aromatic Carboxylic Acids.

Rabina Basnet, Karl Golian, Jessica Sampson, Jessica M Hoover

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rabina BasnetDepartment of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States.
Karl GolianDepartment of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States.
Jessica SampsonHigh Throughput Experimentation Center, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0001-5273-6843
Jessica M HooverDepartment of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States.ORCID 0000-0003-0254-5090

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Understanding Coupling Reactions of HeteroarylsR35GM133566 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HOOVER, JESSICA M · 2019 to 2023
$1.3M
NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R35 GM133566
6 · The paper itself

Abstract

Decarboxylative amination reactions offer the opportunity to access (hetero)aromatic amines from readily available carboxylic acid starting materials. However, the reliance of the Curtius rearrangement on organoazides introduces safety concerns, while more recent transition-metal-mediated approaches suffer from high reaction temperatures and limited substrate scopes. Here, we demonstrate a room-temperature decarboxylative amination to generate a wide array of primary (hetero)aromatic amines mediated by

Identifiers

PMID41677440
PMCPMC12928259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.