Evidence map›Paper›PMID 41677371›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CircRSU1 Activates the hnRNPA1/HIF-1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma.

Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuting XueThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Danduo WeiThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Yongzhi ZhaoThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jinchang PanThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Hanyuan ZhangThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Niya LiuThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jianjuan ZhangThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jiaxin LiuThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jianping JinThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Mu XiaoThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Xinhua FengThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.
Aifu LinCancer Center, Zhejiang University, Hangzhou, Zhejiang Province, China.
Lei ZhaoShandong Cancer Hospital and Institute, Shandong Cancer Hospital of Shandong First Medical University, Jinan, Shandong Province, China.
Stephanie RoesslerInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Junfang JiThe MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Key Laboratory of Molecular Cancer Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, China.ORCID https://orcid.org/0000-0002-3071-6494

Funding

China Postdoctoral Science Foundation 2025M782778German Cancer Aid (Deutsche Krebshilfe) project 70113922German Research Foundation (DFG) project 469332207German Research Foundation (DFG) project 493697503'Leading Goose' R&D Program of Zhejiang Province 2023C03052National Natural Science Foundation of China 82073055National Natural Science Foundation of China 82361148723
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly lethal malignancy with obvious heterogeneity features. This study aims to identify circRNAs with key roles in promoting HCC malignancy and stemness properties. Through circRNA profiling comparison in HCC patients and functional screening in HCC cells, circRSU1 emerges as the top candidate. It exhibits a significant higher expression level in tumor tissues compared to adjacent non-tumor liver tissues from HCC patients. Functionally, circRSU1 promotes a spectrum of HCC malignant phenotypes both in vitro and in vivo, including an enrichment of CD24

Indexed as

Carcinoma, HepatocellularCD24 AntigenHeterogeneous Nuclear Ribonucleoprotein A1Hypoxia-Inducible Factor 1, alpha SubunitLiver NeoplasmsNeoplastic Stem CellsAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceSignal TransductionCD24 AntigenCD24 protein, humanHeterogeneous Nuclear Ribonucleoprotein A1HIF1A protein, humanhnRNPA1 protein, humanHypoxia-Inducible Factor 1, alpha SubunitCD24circRSU1hepatocellular carcinomaHIF‐1αhnRNPA1

Identifiers

PMID41677371
PMCPMC13088275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.