ArticleCartilage2026
Collagen Type II-Derived Telopeptides Cause Tissue Damage in Human Cartilage Cultures Established From Total Arthroplasty.
Article in Cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveTo determine whether telopeptides of collagen type II could induce osteoarthritic tissue damage via receptor for the native protein by using human articular cartilage.MethodsCartilage slices were harvested from patients receiving total arthroplasty. Cartilage tissue cultures or primary chondrocyte cultures were treated with 30 µM N- or C-telopeptide (NT or CT) for 7 days or for 24 h. Loss of proteoglycan (PG) from cartilage was evaluated with 1,9-dimethylmethylene blue (DMMB) assay. Conditioned media or cell lysates were measured for levels of matrix metalloproteinases (MMPs), MMP-3 and MMP-13, or integrin beta-1 (ITGB1) with Western blotting or real-time polymerase chain reaction (PCR).ResultsEither NT or CT could induce significant loss of PG from cartilage than did phosphate-buffered saline (PBS), the delivery vehicle (18.45 ± 6.58 or 15.50 ± 4.91 µg PG/mg wet cartilage treated by NT or CT vs. 25.61 ± 4.14 µg PG/mg wet cartilage treated by PBS;
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