Evidence map›Paper›PMID 41677277›Full record

ReviewClinical microbiology reviews2026

Fungal diagnostic stewardship in immunocompromised populations: a focus on molds and dimorphic fungi.

Julie M Steinbrink, Daniel Z Friedman, George R Thompson, Carol A Kauffman, Barbara D Alexander, Kimberly Hanson, Hannah Imlay, Mycoses Study Group Education & Research Consortium (MSGERC)

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julie M SteinbrinkDivision of Infectious Diseases, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0003-0771-3647
Daniel Z FriedmanSection of Infectious Diseases and Global Health, University of Chicago Medicine, Chicago, Illinois, USA.
George R ThompsonDivision of Infectious Diseases, Department of Medicine, University of California, Davis, Sacramento, California, USA.ORCID 0000-0001-8518-5750
Carol A KauffmanDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Barbara D AlexanderDivision of Infectious Diseases, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Kimberly HansonDivision of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Hannah ImlayDivision of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Mycoses Study Group Education & Research Consortium (MSGERC)

Funding

Novel Host-Response Biomarker Diagnostics for Invasive AspergillosisK23AI187748 · NIAID · DUKE UNIVERSITY · PI Julie Marie Steinbrink · 2025 to 2026
$363k
National Institute of Allergy and Infectious Diseases K23-AI187748NIAID NIH HHS K23 AI187748
6 · The paper itself

Abstract

SUMMARYInvasive fungal diseases cause severe illness and death in immunocompromised patients. Antifungal use is increasingly common, as is fungal diagnostic testing. However, these efforts have not been guided by traditional stewardship efforts akin to those used for bacterial infections. Fungal diagnostic stewardship can have a significant impact on the care of vulnerable patients, including decreasing unnecessary testing while increasing appropriate testing and improving testing strategies to reduce diagnostic errors. In this review, we discuss the most frequently used fungal diagnostic assays for molds and dimorphic fungal infections, their diagnostic performance for these organisms in immunocompromised hosts, and strategies to improve diagnostic stewardship and ultimately patient outcomes.

Indexed as

Antimicrobial StewardshipDiagnostic Tests, RoutineFungiImmunocompromised HostMycosesAntifungal AgentsHumansAntifungal Agentsdiagnostic stewardshipdimorphic fungifungal diagnosticsimmunocompromised hostsmolds

Identifiers

PMID41677277
PMCPMC12912774

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.