Evidence map›Paper›PMID 41677257›Full record

ArticleAntimicrobial agents and chemotherapy2026

Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application.

Sabiha R Mim, Valdeene Vieira Santos, Laiz Campos Pereira, Kiana Pica, Aline Lorena Lourenço Dos Santos Miranda, Helenita Costa Quadros, Diogo Rodrigo Magalhaes Moreira, Francine Johansson Azeredo

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabiha R Mim *Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.ORCID 0009-0005-9359-8527
Valdeene Vieira Santos *Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
Laiz Campos PereiraPharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
Kiana PicaCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Aline Lorena Lourenço Dos Santos MirandaFiocruz, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil.
Helenita Costa QuadrosDepartment of Technology and Social Sciences, State University of Bahia, Juazeiro, Bahia, Brazil.
Diogo Rodrigo Magalhaes MoreiraFiocruz, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil.ORCID 0000-0003-3323-4404
Francine Johansson AzeredoCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.ORCID 0000-0003-3625-0186

Funding

CNPq 422821/2025-0CNPq 440227/2022-4CSRD VA 1
6 · The paper itself

Abstract

A combination between artesunate (AS) and mefloquine (MQ) (ASMQ) is widely employed for the treatment of uncomplicated

Indexed as

AntimalarialsArtemisininsMalariaMefloquineAnimalsArtesunateDrug Therapy, CombinationFemaleMicePlasmodium bergheiAntimalarialsArtemisininsArtesunateMefloquineantimalarial combination therapyPK/PD modelingpreclinical efficacytranslational pharmacology

Identifiers

PMID41677257
PMCPMC12959152

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.