Evidence map›Paper›PMID 41677253›Full record

ArticlemSystems2026

Screening of exogenous nutrients for pathogenic bacteria and development of highly active bactericides.

Yao Ruan, Miao Zhang, Zhenyang Ge, Ting Cheng, Hao Tang, Zhi Zhang, Hailong Yu, Jie Yuan, Haoran Yin, Yiran Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yao Ruan *National Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.ORCID 0000-0003-3675-8764
Miao Zhang *College of Chemistry, Huazhong Agricultural University, Wuhan, Hubei Province, People's Republic of China.
Zhenyang Ge *National Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Ting ChengNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Hao TangNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Zhi ZhangNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Hailong YuNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Jie YuanCollege of Chemistry, Huazhong Agricultural University, Wuhan, Hubei Province, People's Republic of China.
Haoran YinNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Yiran ZhangNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Shuaiyang WangNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.
Shengzhen XuCollege of Chemistry, Huazhong Agricultural University, Wuhan, Hubei Province, People's Republic of China.
Minhui CaoCollege of Chemistry, Huazhong Agricultural University, Wuhan, Hubei Province, People's Republic of China.ORCID 0000-0001-8374-642X
Qingye ZhangNational Key Laboratory of Agricultural Microbiology, National Engineering Research Center of Microbial Pesticides, Huazhong Agricultural University, Wuhan, People's Republic of China.ORCID 0000-0002-9596-590X

Funding

Fundamental Research Funds for the Central Universities 2662022XXYJ007Fundamental Research Funds for the Central Universities 2662024JC009National Key Research and Development Program of China 2024YFD1200200
6 · The paper itself

Abstract

The inherent barriers posed by bacterial outer membranes, efflux pumps, and biofilm matrices significantly limit the clinical efficacy of antimicrobial agents, underscoring the urgent need for strategies to enhance drug penetration. Integrating pathogen-specific exogenous nutrients with conventional antibiotics has emerged as a promising approach, facilitating the targeted delivery and enhanced efficacy of antimicrobial compounds. In this study, we aimed to improve antimicrobial efficacy by enhancing transmembrane transport. First, we comprehensively compared various genome-scale metabolic reconstruction methods to identify the optimal approach. Subsequently, we enhanced our previous approach to identify exogenous nutrients by integrating topological screening, flux scoring, and chemical structure analysis. Key exogenous nutrients were identified for three pathogens: urea for

Indexed as

Anti-Bacterial AgentsBacteriaNutrientsAcinetobacter baumanniiMicrobial Sensitivity TestsPseudomonas aeruginosaSalmonella entericaSuccinic AcidUreaAnti-Bacterial AgentsSuccinic AcidUreaantibiotic resistancedrug developmentexogenous nutrientsgenome-scale metabolic modeltransmembrane transport

Identifiers

PMID41677253
PMCPMC13011427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.