Evidence map›Paper›PMID 41677164›Full record

Trial reportBipolar disorders2026

Potential Impact of Childhood Abuse on Quality of Life During Mood-Stabilising Treatment in Individuals Living With Bipolar Disorder.

Anna L Wrobel, Olivia M Dean, Mojtaba Lotfaliany, Michael Berk, Louisa G Sylvia, Michael E Thase, Thilo Deckersbach, Mauricio Tohen, Melvin G McInnis, James H Kocsis and 4 more

Registry-linked trialAbstract readClinical Trial, Phase IVRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01331304 (Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer And a Classic Mood Stabilizer for Bipolar Disorder), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01331304 phase4completednot on this map

Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer And a Classic Mood Stabilizer for Bipolar Disorder

TypeinterventionalSponsorMassachusetts General HospitalRan2010 to 2013Enrolled482ConditionsBipolar DisorderArmsLithium, Quetiapine
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna L WrobelIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-1864-0394
Olivia M DeanIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-2776-3935
Mojtaba LotfalianyIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Michael BerkIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Louisa G SylviaDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-6762-0664
Michael E ThaseDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Thilo DeckersbachUniversity of Applied Sciences, DIPLOMA Hochschule, Bad Sooden-Allendorf, Germany.
Mauricio TohenUniversity of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0001-8049-4351
Melvin G McInnisUniversity of Michigan, Ann Arbor, Michigan, USA.
James H KocsisWeill Cornell Medical College, New York, New York, USA.
Richard C SheltonDepartment of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Susan L McElroyLindner Center of HOPE, Mason, Ohio, USA.
Alyna TurnerIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Andrew A NierenbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2897-0458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a lack of research examining whether childhood abuse affects the quality of life (QoL) of individuals living with bipolar disorder and its improvement over the course of treatment.

methodsData from the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder were used to explore the associations between childhood abuse and multiple domains of QoL among 476 outpatients with bipolar disorder. Rates of change in QoL throughout treatment were explored with a series of Generalised Estimation Equations for repeated measures.

resultsAt baseline, childhood abuse was related to poorer QoL in the domains of subjective feelings of wellbeing, social relationships and general activities-but not in physical health or leisure activities. Throughout treatment, participants with a history of childhood abuse reported significantly worse QoL in the same domains, than participants with no history of childhood abuse. Interestingly, exploratory analyses showed that participants with a history of childhood abuse and a current diagnosis of post-traumatic stress disorder (PTSD) had significantly worse QoL in all domains, than participants with no history of childhood abuse or diagnosis of PTSD. There were no significant differences between groups in change in QoL in any of the domains.

conclusionThis study comprehensively investigated the relationships between a history of childhood abuse and QoL among people with bipolar disorder who were receiving pharmacotherapy. Although the present findings need to be replicated, they suggest significant impairment in several domains of QoL associated with childhood abuse, which has service and treatment implications for trauma-informed care.

trial registrationClinicalTrials.gov identifier: NCT01331304.

Indexed as

Adult Survivors of Child AbuseBipolar DisorderQuality of LifeAdultAntimanic AgentsAntipsychotic AgentsFemaleHumansMaleMiddle AgedStress Disorders, Post-TraumaticAntimanic AgentsAntipsychotic Agentsbipolar disorderchildhood abuselithiumpost‐traumatic stress disorderquality of lifequetiapinetreatment outcomes

Identifiers

PMID41677164
PMCPMC12896086

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.