Trial reportAging cell2026
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial.
Trial report in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06975540 (Study of the Synergy Between Physical Exercise and a Nutritional Supplement for the Prevention and Treatment of Frailty), which is not on this map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Synergy Between Physical Exercise and a Nutritional Supplement for the Prevention and Treatment of Frailty: The ROBUSTNES Study
Who cites it
3 citing papers in PubMed.
- Trial
- Human whole-blood NADNature metabolism · 2026Article
- Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.Frontiers in genetics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical cellular changes, which could help predict frailty onset or the effectiveness of interventions. In this randomized, controlled study, we assessed phenotypical and functional changes in frail individuals before and after a 6-month multidomain lifestyle intervention (nutritional supplement and supervised exercise) vs habitual care. We also analyzed whole-blood methylome, including five epigenetic clocks, a DNA methylation-based telomere length estimator, and the Rate of Epigenetic Aging (REA). Between October 2019 and July 2022, we recruited 47 frail, community-dwelling individuals in Spain. Mean age was 80.2 years (SD 3.1) in the control group (CG; n = 19) and 80.5 years (4.3) in the intervention group (IG; n = 28). Compared with the CG, a significant reduction in frailty, assessed by the SHARE-FI score, was observed in the IG (p < 0.0001). The IG also showed improved grip strength (p = 0.0053), gait speed (p = 0.0125), the Tinetti score (p = 0.0031), and Barthel Index (p = 0.0484). The intervention was also associated with statistically significant improvements in nutritional blood markers, indicators of biological aging, including reduced DNAm PhenoAge (p = 0.0253) and preserved telomere length (p = 0.0246). REA using DNAm PhenoAge indicated an acceleration of epigenetic aging in the CG (p = 0.0300). Other epigenetic clocks showed nonsignificant changes. Our findings suggest potential geroprotective effects of a multidomain intervention and indicate that DNAm PhenoAge and methylation-based telomere length may serve as complementary markers for assessing health span-related changes in frail older adults. Trial Registration: This trial was retrospectively registered: NCT06975540.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.