ArticleProtein science : a publication of the Protein Society2026
The cytokinesis regulator RacGAP1 is a Rac1-specific GAP on membranes.
Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The cytokinesis regulator RacGAP1 is a Rac1-specific GAP on membranes.Protein science : a publication of the Protein Society · 2026Article
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6 authors.
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Abstract
Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid-binding C1 domain and a GTPase-activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 has remained a matter of debate. Rho family GTPases are inactivated by their GAPs on membranes, but the activity and specificity of RacGAP1 have only been studied biochemically in solution. Here, we reconstituted RacGAP1 in a membrane environment, using liposomes and highly purified proteins. Our study reveals that PS is a major lipid required for RacGAP1 membrane-binding in addition to PIP
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