Evidence map›Paper›PMID 41676875›Full record

ReviewActa anaesthesiologica Scandinavica2026

Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.

Jaap van der Heijden, Peter Frykholm

Abstract readReview
In one paragraph

Review in Acta anaesthesiologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jaap van der HeijdenDepartment of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden.ORCID 0000-0002-4205-7131
Peter FrykholmDepartment of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm infants are at increased risk of perioperative mortality and are among the most vulnerable patients anesthesiologists can encounter. The literature on anesthesia practice in preterm infants is limited, mainly focusing on their physiological immaturity and related pharmacodynamics and pharmacokinetics.

aimsOur aim was to gather comprehensive data on the current practice of anesthesia management in preterm infants and, when available, to compare these findings with existing literature or guidelines.

methodsA cross-sectional study was conducted using a structured survey distributed to pediatric anesthesiologists across the Nordic countries between June and November 2024. The survey assessed various aspects of anesthesia practice in preterm patients, including agent dosing for induction and maintenance, perioperative monitoring techniques, and respiratory and circulatory management strategies.

resultsA total of 57 surveys were collected from 14 hospitals, with an estimated response rate of 30.4%. For induction, 15 different combinations were reported, with the most common being fentanyl and sodium thiopental (31.6%). For maintenance, 13 combinations were identified, primarily fentanyl and sevoflurane (47.4%). Anesthetic doses exhibited considerable variability, with up to a 20-fold difference between the lowest and highest doses. Rocuronium and atracurium were used almost equally as neuromuscular blocking agents, although significant variation in dosing intervals was noted. Targeted mean SpO

conclusionThe substantial heterogeneity in anesthesia practice highlighted the need for high-quality research leading to evidence-based protocols and broader consensus to improve safety and quality of care for this vulnerable population. This survey reports on the breadth of practice details for anesthesia management when preterm infants require surgery, from centers in the 5 Nordic countries.

Indexed as

Infant, PrematureAnestheticsCross-Sectional StudiesHumansInfant, NewbornPediatric AnesthesiaScandinavian and Nordic CountriesSurveys and QuestionnairesAnestheticsinductionmaintenancepediatric anesthesiaperioperativepreterm infantsvasopressor

Identifiers

PMID41676875
PMCPMC12895386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.