Evidence map›Paper›PMID 41676816›Full record

ArticleJMA journal2026

Association between Oral Streptococcus Mutans Counts and Proteinuria in Patients with Chronic Kidney Disease: A Pilot Study Using Chlorhexidine.

Taro Misaki, Yuto Suehiro, Shuhei Naka, Daiki Matsuoka, Kana Suehara, Seigo Ito, Yasuyuki Nagasawa, Rena Okawa, Ryota Nomura, Michiyo Matsumoto-Nakano and 1 more

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Article in JMA journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taro MisakiDivision of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Yuto SuehiroJoint Research Laboratory of Science for Oral and Systemic Connection, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.
Shuhei NakaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Daiki MatsuokaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Kana SueharaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Seigo ItoDepartment of Internal Medicine, Japan Self-Defense Force Iruma Hospital, Iruma, Saitama, Japan.
Yasuyuki NagasawaDepartment of General Internal Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Rena OkawaJoint Research Laboratory of Science for Oral and Systemic Connection, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.
Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Michiyo Matsumoto-NakanoDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Kazuhiko NakanoJoint Research Laboratory of Science for Oral and Systemic Connection, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chlorhexidine mouthwash is one of the most widely used anti-microbial agents, reducing oral cavity bacterial load. However, the effects of mouthwash on systemic conditions in patients with chronic kidney disease (CKD) remain unknown. We examined the relationship between Methods: Patients with CKD (n = 57) gargled with mouthwash containing chlorhexidine gluconate three times daily for 1 year. We prospectively investigated the relationship between changes in the number of Results: The number of Conclusions: In this pilot study, a potential association was observed between oral

Indexed as

chlorhexidine mouthwashCKDOral careproteinuriaStreptococcus mutans

Identifiers

PMID41676816
PMCPMC12888961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.