Evidence map›Paper›PMID 41676747›Full record

ArticleNature synthesis2026

Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes.

Yilin Cao, Warabhorn Rodphon, Turki M Alturaifi, Al Vicente Riano D Lisboa, Zhouyang Ren, Job J C Struijs, Hui-Qi Ni, Taras Savchuk, Richard P Loach, Shouliang Yang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature synthesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yilin CaoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0000-0002-4964-0565
Warabhorn Rodphon *Department of Chemistry, The Scripps Research Institute, La Jolla, CA USA.
Turki M Alturaifi *Department of Chemistry, University of Pittsburgh, Pittsburgh, PA USA.
Al Vicente Riano D LisboaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0009-0008-4902-2522
Zhouyang RenDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.
Job J C StruijsDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0000-0002-6051-2927
Hui-Qi NiDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0009-0006-4848-638X
Taras SavchukEnamine Ltd., Kyiv, Ukraine.
Richard P LoachPfizer Medicinal Sciences, Groton, CT USA.
Shouliang YangPfizer Oncology Medicinal Chemistry, San Diego, CA USA.ORCID 0009-0005-0871-7457
Indrawan J McAlpinePfizer Oncology Medicinal Chemistry, San Diego, CA USA.ORCID 0000-0002-4230-4892
Donna G BlackmondDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.
Pavel K MykhailiukEnamine Ltd., Kyiv, Ukraine.ORCID 0000-0003-1821-9011
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA USA.ORCID 0000-0002-8188-632X
K Barry SharplessDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0000-0001-6051-1599
Keary M EngleDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA USA.ORCID 0000-0003-2767-6556

Funding

Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
Controlled Catalytic Functionalization of Alkenes and AlkynesR35GM156483 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Keary Mark Engle · 2025 to 2026
$1.0M
NIGMS NIH HHS R35 GM128779NIGMS NIH HHS R35 GM156483
6 · The paper itself

Abstract

Here we present the ambiphilic reactivity of alkyl sulfonyl fluorides in the stereoselective synthesis of diverse cyclopropanes from olefins, under palladium(II) catalysis. The sulfonyl fluoride functionality serves as both an acidifying group and an internal oxidant within the ambiphile, enabling successive carbopalladation and oxidative addition steps in the catalytic cycle, respectively. The transformation grants access to

Indexed as

Homogeneous catalysisSynthetic chemistry methodology

Identifiers

PMID41676747
PMCPMC12885951

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.