Evidence map›Paper›PMID 41676719›Full record

ArticlebioRxiv : the preprint server for biology2026

Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization.

Aman Patel, Anshul Kundaje

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aman PatelDepartment of Computer Science, School of Engineering, Stanford University.ORCID 0000-0003-2113-3251
Anshul KundajeDepartment of Computer Science, School of Engineering, Stanford University.ORCID 0000-0003-3084-2287

Funding

Predicting context-specific molecular and phenotypic effects of genetic variation through the lens of the cis-regulatory codeU01HG012069 · NHGRI · STANFORD UNIVERSITY · PI Anshul Kundaje · 2021 to 2026
$3.9M
NHGRI NIH HHS U01 HG012069
6 · The paper itself

Abstract

Self-supervised DNA language models (DNALMs) are typically trained at massive scale on whole genomes and long contexts. However, regulatory sequence features are sparse, heterogeneous, and dominated by poorly conserved flexible syntax of short motifs, which can be difficult to learn from genome-wide self-supervision. As a result, annotation agnostic, long-context DNALMs struggle to learn regulatory syntax and can underperform simpler baseline models on key regulatory tasks. We therefore introduce

Identifiers

PMID41676719
PMCPMC12889687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.