Evidence map›Paper›PMID 41676702›Full record

ArticlebioRxiv : the preprint server for biology2026

Moses H Milchberg, Owen A Warmuth, Collin G Borcik, Ruixian Han, Benjamin D Harding, Dhruva D Dhavale, Paul T Kotzbauer, Elizabeth R Wright, Charles D Schwieters, Chad M Rienstra

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Moses H MilchbergDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-4524-2797
Owen A WarmuthDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0001-9731-5487
Collin G BorcikDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-4733-7773
Ruixian HanDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0001-7660-7202
Benjamin D HardingDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-4317-7880
Dhruva D DhavaleDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.ORCID 0000-0002-0096-1085
Paul T KotzbauerDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.ORCID 0000-0001-7155-114X
Elizabeth R WrightDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0003-0712-9475
Charles D SchwietersImaging Sciences Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD, 20817, USA.ORCID 0000-0002-4216-4658
Chad M RienstraDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-9912-5596

Funding

Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4M
Structural Biology of Alpha-Synuclein in Lewy Body DementiaRF1NS110436 · NINDS · WASHINGTON UNIVERSITY · PI KOTZBAUER, PAUL T, RIENSTRA, CHAD M · 2023 to 2023
$4.2M
Predoctoral Training in Molecular BiophysicsT32GM130550 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SENES, ALESSANDRO · 2019 to 2023
$1.5M
Structural Biology and Biophysics of Alpha-Synuclein Fibrils by Solid-State NMRF32GM149118 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BORCIK, COLLIN GRIFFIN · 2023 to 2024
$143k
NIGMS NIH HHS F32 GM149118NIGMS NIH HHS P41 GM136463NIGMS NIH HHS T32 GM130550NINDS NIH HHS RF1 NS110436
6 · The paper itself

Abstract

The pathological hallmark of Parkinson Disease (PD) is the formation of the protein alpha-synuclein (Asyn) into β-sheet rich, self-templating fibrils in the brain. Since the first atomic structure of wild-type Asyn fibrils was determined nearly a decade ago, several other

Indexed as

Alpha-synucleinAmyloidcryo-EMFibrilsParkinson DiseaseSolid-state NMR

Identifiers

PMID41676702
PMCPMC12889639

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.