Evidence map›Paper›PMID 41676686›Full record

ArticlebioRxiv : the preprint server for biology2026

Diverse Microbial Exposure Enhances CD8

Claire E Thefaine, Erin D Lucas, Katharine E Block, Mark Pierson, Emma M Dehm, Matthew A Huggins, Odhrán W Casey, David Zemmour, Stephen C Jameson, Sara E Hamilton and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claire E ThefaineCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Erin D LucasCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Katharine E BlockCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Mark PiersonCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Emma M DehmCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Matthew A HugginsCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Odhrán W CaseyDepartment of Immunology, Harvard Medical School, Boston, MA.
David ZemmourDepartment of Pathology, University of Chicago, Chicago, IL.
Stephen C JamesonCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Sara E HamiltonCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-3768-7622
immgenT Project

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Understanding the functional agility of effector memory CD8 T cellsR01AI155468 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2021 to 2025
$2.8M
Determining factors of inflammation that support the expansion and function of long-lived effector cell CD8 T cells in a mature memory compartmentF32AI178962 · NIAID · UNIVERSITY OF MINNESOTA · PI Erin D Lucas · 2024 to 2026
$255k
NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS F32 AI178962NIAID NIH HHS R01 AI155468NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Mice with normalized microbial exposure (NME) harbor an immune system that more accurately reflects that of humans compared to mice maintained as specific pathogen-free (SPF). An explanation for the observed alterations in the composition of the T cell compartment in NME mice has not been reported. We compared the T cell landscape in NME versus SPF mice at baseline and after acute LCMV infection. Using the immgenT dataset, we found no unique T cell populations in NME, but the landscape shifted towards activated T cells with increased propensity for effector functions and improved pathogen clearance. CD8

Identifiers

PMID41676686
PMCPMC12889659

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.