Evidence map›Paper›PMID 41676684›Full record

ArticlebioRxiv : the preprint server for biology2026

Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome.

Sophie F Hill, Emiola A Enakhimion, Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Sara Wills, Thien Tran, Gordon Fishell, Yating Wang, Ethan M Goldberg

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophie F HillDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-8331-9812
Emiola A EnakhimionCollege of Arts and Sciences, The University of Pennsylvania, Philadelphia, PA.
Elisabetta FurlanisBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.
Min DaiBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.ORCID 0000-0001-7584-5014
Brenda Leyva GarciaBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.
Sara WillsBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.
Thien TranBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.
Gordon FishellBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.ORCID 0000-0002-9640-9278
Yating WangBlavatnik Institute, Department of Neurobiology, Harvard Medical School, Cambridge, MA.
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-7404-735X

Funding

Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndromeR01NS110869 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2019 to 2026
$3.5M
NINDS NIH HHS R01 NS110869
6 · The paper itself

Abstract

Chandelier cells (ChCs) are a rare and highly specialized subtype of inhibitory neuron in the cerebral cortex that specifically and exclusively form synapses onto the axon initial segment of excitatory neurons and thereby exert powerful control of excitability. We applied a newly developed, cell type-specific enhancer element to label ChCs and assess their electrophysiological and morphological properties across development in Dravet Syndrome (

Indexed as

Chandelier cellDravet SyndromeEpilepsyScn1aSodium channel

Identifiers

PMID41676684
PMCPMC12889633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.