Evidence map›Paper›PMID 41676680›Full record

ArticlebioRxiv : the preprint server for biology2026

Epigenetic Gatekeeping of Intestinal Stem Cell Transformation.

Alireza Lorzadeh, Sweta Sharma, Geroge Ye, Sabrina Rabaya, Yun Jee Kang, Ramesh A Shivdasani, Unmesh Jadhav

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alireza LorzadehDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, CA, USA.ORCID 0000-0001-8500-7487
Sweta SharmaDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, CA, USA.
Geroge YeDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, CA, USA.
Sabrina RabayaFaculty of Computing and Data Science, Bostone University, MA, USA.
Yun Jee KangDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Ramesh A ShivdasaniDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Unmesh JadhavDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, CA, USA.

Funding

Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
Coordinate roles of histone H3K27me3 and DNA methylation in intestinal homeostasis and tumorigenesisK01DK113067 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JADHAV, UNMESH · 2018 to 2022
$704k
High resolution characterization of epigenetic dynamics in gastrointestinal cell plasticityR03DK134799 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JADHAV, UNMESH · 2023 to 2024
$243k
NICHD NIH HHS T32 HD060549NIDDK NIH HHS K01 DK113067NIDDK NIH HHS R03 DK134799
6 · The paper itself

Abstract

Widespread cell plasticity recognized in fetal intestinal epithelium is preserved in limited fashion in Wnt-responsive adult stem cells and contributes to tumor initiation, progression, and relapse.

Identifiers

PMID41676680
PMCPMC12889513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.