Evidence map›Paper›PMID 41676674›Full record

ArticlebioRxiv : the preprint server for biology2026

Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds.

William R Smisko, William R Haury, Michele Perni, Rebecca Kalik, Jhelaine Palo, Brandon L Bastien, Jadwiga N Bilchak, Thomas A Jongens, Matthew S Kayser, Michael P Hart

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intrafamilial Variability inInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

William R SmiskoDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
William R HauryDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0009-0002-0656-2234
Michele PerniDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0001-7593-8376
Rebecca KalikDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-8628-1506
Jhelaine PaloDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0009-0009-0267-4256
Brandon L BastienDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-6029-5846
Jadwiga N BilchakDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-9893-1334
Thomas A JongensDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0002-0190-7339
Matthew S KayserAutism Spectrum Program of Excellence, Perelman School of Medicine, Philadelphia, PA USA.
Michael P HartDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.ORCID 0000-0001-8865-3062

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular coordination of adhesion molecules in foraging behaviors and circuitsR35GM146782 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Michael P Hart · 2022 to 2026
$2.0M
NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R35 GM146782NIH HHS P40 OD010440
6 · The paper itself

Abstract

Neurexins are synaptic adhesion molecules associated with vast neurologic changes in humans, including neurodevelopmental delay, autism, schizophrenia, Tourette syndrome, and seizures. The

Identifiers

PMID41676674
PMCPMC12889696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.