ArticlebioRxiv : the preprint server for biology2026
Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.
Stephanie A Herrlinger, Bovey Y Rao, Margaret E Conde Paredes, Anna L Tuttman, Haroon Arain, Erdem Varol, Joseph A Gogos, Attila Losonczy
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Stephanie A HerrlingerDepartment of Neuroscience, Columbia University, New York, NY, United States.
Bovey Y RaoDepartment of Neuroscience, Columbia University, New York, NY, United States.
Margaret E Conde ParedesDepartment of Neuroscience, Columbia University, New York, NY, United States.
Anna L TuttmanDepartment of Neuroscience, Columbia University, New York, NY, United States.
Haroon ArainDepartment of Neuroscience, Columbia University, New York, NY, United States.
Erdem VarolDepartment of Computer Science & Engineering, Tandon School of Engineering, New York University, New York, NY, United States.
Joseph A GogosDepartment of Neuroscience, Columbia University, New York, NY, United States.
Funding
MicroRNA Dysregulation in Pyschiatric Disorders and Cognitive DysfunctionR01MH097879 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A · 2012 to 2021
$5.4MOptimization, application and dissemination of high-speed hybrid multiphoton volumetric imaging technologiesU01NS115530 · NINDS · ROCKEFELLER UNIVERSITY · PI LOSONCZY, ATTILA, VAZIRI, ALIPASHA · 2020 to 2023
$4.7MMicrocircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletionR01MH124047 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A, LOSONCZY, ATTILA · 2020 to 2024
$3.8MExperimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4MControl of Axon Initial Segment in EpilepsyR01NS121106 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2021 to 2025
$3.4MDissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's DiseaseRF1AG080818 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FUSI, STEFANO, HEN, RENE · 2023 to 2023
$2.5MActivity-dependent endocannabinoid control in epilepsyR01NS131728 · NINDS · STANFORD UNIVERSITY · PI Attila Losonczy, IVAN SOLTESZ · 2023 to 2026
$2.3MLocal Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the HippocampusR01NS133381 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Attila Losonczy, IVAN SOLTESZ · 2026 to 2026
$752kTranscriptional basis of stereotyped neural architecturesR00MH128772 · NIMH · NEW YORK UNIVERSITY · PI Erdem Varol · 2024 to 2026
$734kNIA NIH HHS RF1 AG080818NIMH NIH HHS R00 MH128772NIMH NIH HHS R01 MH097879NIMH NIH HHS R01 MH124047NIMH NIH HHS R01 MH124867NINDS NIH HHS R01 NS121106NINDS NIH HHS R01 NS131728NINDS NIH HHS R01 NS133381NINDS NIH HHS U01 NS115530
6 · The paper itselfAbstract
Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments, including episodic memory dysfunction. Place cell activity of excitatory pyramidal neurons in the hippocampus supporting episodic memory is impaired in a mouse model for the 22q11.2 deletion (
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PMID41676673
PMCPMC12889890
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