Evidence map›Paper›PMID 41676672›Full record

ArticlebioRxiv : the preprint server for biology2026

A MET-Targeted Variable New Antigen Receptor (VNAR) Theranostic for Non-Small Cell Lung Cancer.

Rachel L Minne, Jayden L West, Natalie Y Luo, Kwangok P Nickel, Gihan S Gunaratne, Kendahl L Ott, Joseph P Gallant, Kendall E Barrett, Caroline M Mork, Saahil Javeri and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Rachel L MinneDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Jayden L WestUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Natalie Y LuoDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Kwangok P NickelDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Gihan S GunaratneDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Kendahl L OttUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Joseph P GallantUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Kendall E BarrettDepartment of Radiology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Caroline M MorkDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Saahil JaveriDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Madalynn R WopatDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Loren D Rivera LopezDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Will A ToscanoDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Nina C ZitzerDepartment of Pathobiological Sciences. University of Wisconsin School of Veterinary Medicine, Madison, WI-53705.
Ohyun KwonDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.ORCID 0000-0002-0334-105X
Jordan TeagueDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Brittany BunkerWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, WI 53715.
Jessica M PhillipsWisconsin National Primate Research Center, University of Wisconsin-Madison; Madison, WI 53715.
Malick Bio IdrissouDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Hansel Comas RojasDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Jason C MixdorfDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Eduardo Aluicio-SarduyDepartment of Radiology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Jonathan W EngleDepartment of Radiology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.ORCID 0000-0002-3399-7228
Bryan BednarzDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Reinier HernandezDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.ORCID 0000-0002-0729-2179
Randall J KimpleDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Andrew M BaschnagelDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.
Aaron M LeBeauUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health; Madison, WI 53705.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Project 3: Modulation of the head and neck tumor immune microenvironment by targeting the TAM family of receptorsP50CA278595 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI David J Beebe · 2022 to 2026
$12.5M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Improving the translational value of head and neck cancer patient-in-mouse modelsR37CA255330 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Randall J. Kimple · 2021 to 2026
$3.5M
Graduate Training in Molecular and Cellular PharmacologyT32GM141013 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya, Aaron Matthew LeBeau · 2021 to 2026
$3.2M
Targeting CD133 for imaging and therapy in prostate cancerR01CA237272 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LEBEAU, AARON MATTHEW · 2019 to 2023
$1.8M
Cyclic Peptide Protease Inhibitors for the Treatment of Prostate CancerR01CA245922 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LEBEAU, AARON MATTHEW · 2020 to 2024
$1.7M
Novel Radioimmunotherapy Strategies for Prostate CancerR01CA233562 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LEBEAU, AARON MATTHEW · 2019 to 2023
$1.7M
Shark Radiotherapy for the Treatment of Triple-Negative Breast CancerR01CA295576 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Aaron Matthew LeBeau · 2025 to 2026
$1.3M
UW SPECT/CT AcquisitionS10OD028670 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEICHERT, JAMEY P · 2020 to 2020
$598k
NCI NIH HHS P30 CA014520NCI NIH HHS P50 CA278595NCI NIH HHS R01 CA233562NCI NIH HHS R01 CA237272NCI NIH HHS R01 CA245922NCI NIH HHS R01 CA295576NCI NIH HHS R37 CA255330NIGMS NIH HHS R01 GM129325NIGMS NIH HHS T32 GM141013NIH HHS P51 OD011106NIH HHS S10 OD028670
6 · The paper itself

Abstract

The MET receptor tyrosine kinase is mutated or amplified in ~6% of non-small cell lung cancer (NSCLC) and overexpressed in ~80% of all NSCLC cases. A theranostic agent that can both see and treat MET-altered NSCLC has never been described before in the literature. Here, we report a shark-derived single-domain variable new antigen receptor (VNAR) for MET with theranostic applications. Following the immunization of a juvenile nurse shark (

Identifiers

PMID41676672
PMCPMC12889510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.